Immanuel Feyi-Waboso has been ruled out of England's pivotal clash with Scotland and is in danger of missing the entire Six Nations.
Feyi-Waboso suffered a hamstring injury in training last week, resulting in his withdrawal from the starting XV for Saturday's 48-7 victory over Wales.
Head coach Steve Borthwick is well stocked for wings with Henry Arundell scoring a hat-trick of tries in the round-one showdown at Allianz Stadium and Tom Roebuck making a successful comeback from a broken toe. Tommy Freeman and Elliot Daly are also options.
But England would still want to field their main strike weapon for the attempt to claim a first win at Murrayfield since 2020 and, with the rest of the Championship in mind, will be hoping for a positive update when Feyi-Waboso sees a specialist.
"It looks like Manny will be out for a number of weeks. I don't know how many, but it's a number rather than a single week, which is disappointing," Borthwick said.
"But that's unfortunately the nature of elite sport - there are injuries and then you have to adapt."
Feyi-Waboso was left out of England's updated 36-man squad named on Sunday and will continue his rehabilitation at his club Exeter.
The setback is partially offset by the return of Fin Smith and Ollie Lawrence from respective calf and knee injuries, although involving them in the starting XV would mean dropping George Ford and rejigging the backline.
Borthwick revealed that Ellis Genge's withdrawal at half-time was a precautionary measure relating to an unspecified niggle and he will be available to face Scotland.
George Furbank, however, will not be involved as he continues rehabilitation for a calf problem.
England have lost on three of their last four visits to Murrayfield with the Calcutta Cup proving to be a tortuous fixture in recent years, but on Saturday they head to the Scottish capital armed with a 12-Test winning run.
England's challenge before the Six Nations was clear: reach their round-five clash with France in Paris with a Grand Slam still on the table.
Looking that far ahead, though, is a sure way to derail their ambitions - especially with challenges more difficult than Wales, beginning with Saturday's trip to Murrayfield, looming.
England may enter the Calcutta Cup as holders and Scotland may be reeling from their 18‑15 opening‑round defeat in Italy, but England have not won in Edinburgh since 2020.
That victory came two years before Borthwick's appointment, and the England head coach outlined a number of areas for improvement before travelling to Murrayfield.
"Defensively we were excellent," he said. "We know Wales have got so many dangerous players and pace out wide and we shut them down really well.
"Our kicking game was good and the set‑piece did a good job, but there's plenty of room for improvement. What is really pleasing is we created loads of opportunities and we can get better at converting those.
"Especially in that second half, we didn't convert the opportunities in the manner I would like us to. There is plenty for us to go and work on."
One game in and England are looking every inch the title contenders talked up inside and outside the camp, with their destructive first half in a savaging of Wales confirmation of their resurgence under Borthwick. Steve Tandy's side were woeful, but England still displayed patience and ruthlessness as they built an unassailable lead.
Tries were left out on the field after the interval, their bench failed to provide any impact and Freeman at outside centre is still a work in progress, but they will rightly head to Murrayfield on Saturday with a swagger after such an emphatic start to the tournament.
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